49697-38-3

49697-38-3 structure

Name: Rimexolone
Chemical Name: Rimexolone
CAS Number: 49697-38-3
Molecular Formula: C₂₄H₃₄O₃
Molecular Weight: 370.525
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-09-14 18:03:01
Modify Date: 2024-01-10 12:06:47
Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2].

Name	Rimexolone
Synonyms	Rimexolone (11β,16α,17β)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one 11β-Hydroxy-16α,17α-dimethyl-17-propionylandrosta-1,4-dien-3-one 11b-Hydroxy-16a,17a-dimethyl-17-propionylandrosta-1,4-dien-3-one (8S,9S,10R,11S,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (8S,9S,10R,11S,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one Asoprisnil ecamate Androsta-1,4-dien-3-one, 11-hydroxy-16,17-dimethyl-17-(1-oxopropyl)-, (11β,16α,17β)- (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tétraméthyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-3-one 11β-Hydroxy-16α,17,21-trimethyl-1,4-pregnadien-3,20-dion (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) (8S,9S,10R,13S,14S,16R,17S)-11-Hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) VEXOL

Description	Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy[1].
In Vivo	Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis[1]. Animal Model: Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis[1] Dosage: 5, 25, 50, 150, 250, 450 μg/mouse Administration: Intraarticular injection, once Result: Suppressed the arthritis in a dose-dependent manner. Significantly prevented osteophyte formation at 450 and 150 μg. Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis.
References	[1]. Joosten LA, et al. Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonide. Agents Actions. 1990 Aug;31(1-2):135-42. [2]. Foster CS, et al. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol. 1996 Aug;122(2):171-82.