283172-68-9

283172-68-9 structure

Name: WD2000-012547
Chemical Name: 2-phenyl-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one
CAS Number: 283172-68-9
Molecular Formula: C₁₇H₁₄N₂O
Molecular Weight: 262.30600
Catalog: Research Areas Cancer
Create Date: 2017-07-02 15:40:24
Modify Date: 2024-01-10 11:54:16
WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.

Name	2-phenyl-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-one
Synonyms	WD2000-012547

Description	WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221.
Related Catalog	Research Areas >> Cancer
Target	PARP-1:8.221 (pKi)
In Vitro	Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pKi of 8.221[1].
References	[1]. Fatima S, et al. Multiple receptor conformation docking, dock pose clustering and 3D QSAR studies on human poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. J Recept Signal Transduct Res. 2014 Oct;34(5):417-30.