133429-58-0

133429-58-0 structure

Name: Z-LLF-CHO
Chemical Name: Z-LLF-CHO
CAS Number: 133429-58-0
Molecular Formula: C₂₉H₃₉N₃O₅
Molecular Weight: 509.64
Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
Create Date: 2024-01-11 22:19:31
Modify Date: 2024-01-11 22:19:31
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor[1][2].

Name	Z-LLF-CHO

Description	Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
References	[1]. Orlowski M, et al. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. Biochemistry. 1993 Feb 16;32(6):1563-72. [2]. Ding L, et al. Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2005 Sep;37(9):1881-9.

Molecular Formula	C₂₉H₃₉N₃O₅
Molecular Weight	509.64