1045857-53-1

1045857-53-1 structure

Name: XM462
Chemical Name: XM462
CAS Number: 1045857-53-1
Molecular Formula: C₂₅H₅₁NO₃S
Molecular Weight: 445.74
Catalog: Research Areas Cancer
Create Date: 2024-02-27 19:23:26
Modify Date: 2026-08-14 12:05:10
XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor[1][2].

Name	XM462

Description	XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 8.2 μM (dihydroceramide desaturase in vitro); 0.78 μM (dihydroceramide desaturase in cultured cells)[1].
References	[1]. Munoz-Olaya JM, et al. Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem. 2008 Jun;3(6):946-53. [2]. Camacho L, et al. 3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate. Bioorg Med Chem. 2012 May 15;20(10):3173-9.

Molecular Formula	C₂₅H₅₁NO₃S
Molecular Weight	445.74