752984-66-0

752984-66-0 structure

Name: Spinoxin
Chemical Name: Spinoxin
CAS Number: 752984-66-0
Molecular Formula: C₁₄₇H₂₃₆N₄₈O₄₆S₉
Molecular Weight: 3700.33
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2024-01-08 13:51:20
Modify Date: 2024-01-08 13:51:20
Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC50 = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers[1].

Name	Spinoxin

Description	Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC50 = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Kv1.3:63 nM (IC50)
References	[1]. Steve Peigneur, et al. Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning. Biochemistry. 2016 May 31;55(21):2927-35.

Molecular Formula	C₁₄₇H₂₃₆N₄₈O₄₆S₉
Molecular Weight	3700.33