2245237-61-8

2245237-61-8 structure

Name: SOS1 agonist-1
Chemical Name: SOS1 agonist-1
CAS Number: 2245237-61-8
Molecular Formula: C₂₆H₂₉BrClFN₄O₂
Molecular Weight: 563.89
Catalog: Research Areas Cancer
Create Date: 2024-02-09 11:36:10
Modify Date: 2025-08-25 12:46:19
SOS1 agonist-1 (compound 79) is an agonist for the Son of sevenless homologue SOS1. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP to GTP on RAS and regulates RAS activation. SOS1 agonists increase nucleotide exchange on RAS, enhance cellular RAS-GTP levels, and trigger biphasic signaling changes in ERK1/2 phosphorylation. Play an anti-cancer role[1].

Name	SOS1 agonist-1

Description	SOS1 agonist-1 (compound 79) is an agonist for the Son of sevenless homologue SOS1. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP to GTP on RAS and regulates RAS activation. SOS1 agonists increase nucleotide exchange on RAS, enhance cellular RAS-GTP levels, and trigger biphasic signaling changes in ERK1/2 phosphorylation. Play an anti-cancer role[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Son of sevenless homologue 1 (SOS1)[1]
References	[1]. Hodges TR, Abbott JR, Little AJ, Sarkar D, Salovich JM, Howes JE, Akan DT, Sai J, Arnold AL, Browning C, Burns MC, Sobolik T, Sun Q, Beesetty Y, Coker JA, Scharn D, Stadtmueller H, Rossanese OW, Phan J, Waterson AG, McConnell DB, Fesik SW. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61(19):8875-8894.

Molecular Formula	C₂₆H₂₉BrClFN₄O₂
Molecular Weight	563.89