2848664-42-4

2848664-42-4 structure

Name: QL-1200186
Chemical Name: QL-1200186
CAS Number: 2848664-42-4
Molecular Formula: C₂₆H₂₇N₇O₃
Molecular Weight: 485.54
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2024-01-08 11:17:49
Modify Date: 2025-08-26 23:11:28
QL-1200186 is anorally activeand selective inhibitor ofTYK2. Oral administration of QL-1200186, dose-dependently inhibitsinterferon-γ(IFNγ) production afterinterleukin-12(IL-12) challenge and significantly ameliorates skin lesions in psoriatic mice[1].

Name	QL-1200186

Description	QL-1200186 is anorally activeand selective inhibitor ofTYK2. Oral administration of QL-1200186, dose-dependently inhibitsinterferon-γ(IFNγ) production afterinterleukin-12(IL-12) challenge and significantly ameliorates skin lesions in psoriatic mice[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
References	[1]. Chen CX, et al. A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways. Cell Commun Signal. 2023;21(1):287. Published 2023 Oct 16.

Molecular Formula	C₂₆H₂₇N₇O₃
Molecular Weight	485.54