2127107-15-5

2127107-15-5 structure

Name: PHI-101
Chemical Name: PHI-101
CAS Number: 2127107-15-5
Molecular Formula: C₁₉H₁₉FN₄O₂S
Molecular Weight: 386.44
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FLT3
Create Date: 2023-12-31 18:07:49
Modify Date: 2024-01-21 11:37:27
PHI-101 is an orally active FLT3 inhibitor that overcomes resistance to multiple drug-resistant mutations. PHI-101 potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. PHI-101 has potential for research in relapsed or refractory acute myeloid leukemia (AML)[1].

Name	PHI-101

Description	PHI-101 is an orally active FLT3 inhibitor that overcomes resistance to multiple drug-resistant mutations. PHI-101 potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. PHI-101 has potential for research in relapsed or refractory acute myeloid leukemia (AML)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
References	[1]. Nam K Y, et al. PHI-101 Is a Potent Third-Generation FLT3 Inhibitor Developed to Overcome Resistance in Acute Myeloid Leukemia[J]. Blood, 2020, 136: 28.

Molecular Formula	C₁₉H₁₉FN₄O₂S
Molecular Weight	386.44