2738583-25-8

2738583-25-8 structure

Name: Enpp-1-IN-19
Chemical Name: Enpp-1-IN-19
CAS Number: 2738583-25-8
Molecular Formula: C₁₆H₁₆N₄O₃S
Molecular Weight: 344.39
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2024-01-01 13:33:37
Modify Date: 2024-01-01 13:33:37
Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].

Name	Enpp-1-IN-19

Description	Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> Immunology/Inflammation >> STING
Target	ENPP1[1]
References	[1]. Cho Y et al. Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy. J Med Chem. 2023 Nov 23;66(22):15141-15170.

Molecular Formula	C₁₆H₁₆N₄O₃S
Molecular Weight	344.39