2376399-42-5

2376399-42-5 structure

Name: Emavusertib hydrochloride
Chemical Name: Emavusertib hydrochloride
CAS Number: 2376399-42-5
Molecular Formula: C₂₄H₂₆ClN₇O₅
Molecular Weight: 527.96
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2023-12-31 07:49:26
Modify Date: 2024-01-03 11:54:24
Emavusertib (CA-4948) hydrochloride is a selective, potent and orally active IRAK4/FLT3 inhibitor. Emavusertib hydrochloride has an IC50 of 57 nM for IRAK4 in a FRET kinase assay. Emavusertib hydrochloride shows anti-tumor activity[1][2][3].

Name	Emavusertib hydrochloride

Description	Emavusertib (CA-4948) hydrochloride is a selective, potent and orally active IRAK4/FLT3 inhibitor. Emavusertib hydrochloride has an IC50 of 57 nM for IRAK4 in a FRET kinase assay. Emavusertib hydrochloride shows anti-tumor activity[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3 Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:57 nM (IC50)
References	[1]. Wiese MD, et al. Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis. Expert Opin Investig Drugs. 2020 Apr 17:1-8. [2]. Guidetti F, et al. Targeting IRAK4 with Emavusertib in Lymphoma Models with Secondary Resistance to PI3K and BTK Inhibitors. J Clin Med. 2023 Jan 4;12(2):399. [3]. Parrondo RD, et al. IRAK-4 inhibition: emavusertib for the treatment of lymphoid and myeloid malignancies. Front Immunol. 2023 Oct 26;14:1239082.

Molecular Formula	C₂₄H₂₆ClN₇O₅
Molecular Weight	527.96