1296734-08-1

1296734-08-1 structure

Name: CU06-1004
Chemical Name: CU06-1004
CAS Number: 1296734-08-1
Molecular Formula: C₃₇H₅₄O₈
Molecular Weight: 626.82
Catalog: Research Areas Cancer
Create Date: 2024-01-01 12:25:59
Modify Date: 2024-01-01 12:25:59
CU06-1004 (Sac-1004) is an orally active endothelial dysfunction blocker. CU06-1004 ameliorates endothelial dysfunction by inhibiting hyperpermeability and inflammation, and is potent in inhibiting vascular leakage and inflammation in various animal models, such as diabetic retinopathy, stroke, cancer, and inflammatory bowel disease. CU06-1004 ameliorates CDAA-induced mouse model of NASH. CU06-1004 also improves cardiac function[1][2][3].

Name	CU06-1004

Description	CU06-1004 (Sac-1004) is an orally active endothelial dysfunction blocker. CU06-1004 ameliorates endothelial dysfunction by inhibiting hyperpermeability and inflammation, and is potent in inhibiting vascular leakage and inflammation in various animal models, such as diabetic retinopathy, stroke, cancer, and inflammatory bowel disease. CU06-1004 ameliorates CDAA-induced mouse model of NASH. CU06-1004 also improves cardiac function[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
References	[1]. Zhang H, et al. CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia-reperfusion injury. Exp Mol Med. 2022 Jan;54(1):23-34. [2]. Kim Y, et al. Efficacy of CU06-1004 via regulation of inflammation and endothelial permeability in LPS-induced acute lung injury. J Inflamm (Lond). 2023 Apr 6;20(1):13. [3]. Bae CR, et al. Correction: The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice. PLoS One. 2021 Apr 5;16(4):e0249747.

Molecular Formula	C₃₇H₅₄O₈
Molecular Weight	626.82