1906915-49-8

1906915-49-8 structure

Name: BQZ-485
Chemical Name: BQZ-485
CAS Number: 1906915-49-8
Molecular Formula: C₃₂H₃₉NO₃
Molecular Weight: 485.66
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2024-03-12 18:52:58
Modify Date: 2025-12-01 17:08:49
BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events[1].

Name	BQZ-485

Description	BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Yong Sun, et al. Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy. JACS Au 2023, September 26, 2023.

Molecular Formula	C₃₂H₃₉NO₃
Molecular Weight	485.66