2730432-75-2

2730432-75-2 structure

Name: ALK/EGFR-IN-2
Chemical Name: ALK/EGFR-IN-2
CAS Number: 2730432-75-2
Molecular Formula: C₂₇H₃₄ClN₇O₃S
Molecular Weight: 572.12
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2024-01-12 15:36:58
Modify Date: 2024-01-12 15:36:58
ALK/EGFR-IN-2 is a potent dual inhibitor of ALK and EGFR. ALK/EGFR-IN-2 induces apoptosis and G0/G1 cell cycle arrest in cancer cells. ALK/EGFR-IN-2 significantly inhibits the cell proliferation of H1975, PC9, and Baf3-EML4-ALK cancer cell lines with IC50s of 0.0034, 0.0065, and 0.0018 μM, respectively[1].

Name	ALK/EGFR-IN-2

Description	ALK/EGFR-IN-2 is a potent dual inhibitor of ALK and EGFR. ALK/EGFR-IN-2 induces apoptosis and G0/G1 cell cycle arrest in cancer cells. ALK/EGFR-IN-2 significantly inhibits the cell proliferation of H1975, PC9, and Baf3-EML4-ALK cancer cell lines with IC50s of 0.0034, 0.0065, and 0.0018 μM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
References	[1]. An B, et al. Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer. Bioorg Chem. 2023 Sep;138:106653.

Molecular Formula	C₂₇H₃₄ClN₇O₃S
Molecular Weight	572.12