2614183-36-5

2614183-36-5 structure

Name: VISTA-IN-2
Chemical Name: VISTA-IN-2
CAS Number: 2614183-36-5
Molecular Formula: C₂₃H₂₃N₃O
Molecular Weight: 357.45
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2023-11-04 18:05:35
Modify Date: 2025-08-27 09:45:38
VISTA-IN-2 (Compound 1) is an inhibitor of V-domain Ig suppressor of T-cell activation (VISTA). VISTA-IN-2 induces VISTA degradation in cells through an autophagic mechanism. VISTA-IN-2 rescues VISTA-mediated immunosuppression, and enhances antitumor activity of immune cells. VISTA-IN-2 also activates the antitumor immunity and inhibits tumor growth in a CT26 mouse model[1].

Name	VISTA-IN-2

Description	VISTA-IN-2 (Compound 1) is an inhibitor of V-domain Ig suppressor of T-cell activation (VISTA). VISTA-IN-2 induces VISTA degradation in cells through an autophagic mechanism. VISTA-IN-2 rescues VISTA-mediated immunosuppression, and enhances antitumor activity of immune cells. VISTA-IN-2 also activates the antitumor immunity and inhibits tumor growth in a CT26 mouse model[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology
References	[1]. Wang T, et al. Novel Benzimidazoles as Potent Small-Molecule Inhibitors and Degraders of V-Domain Ig Suppressor of T-Cell Activation (VISTA). J Med Chem. 2023 Aug 18.

Molecular Formula	C₂₃H₂₃N₃O
Molecular Weight	357.45