2765535-21-3

2765535-21-3 structure

Name: PD-1/PD-L1-IN-32
Chemical Name: PD-1/PD-L1-IN-32
CAS Number: 2765535-21-3
Molecular Formula: C₂₉H₂₅ClFN₃O₃
Molecular Weight: 517.98
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2023-11-08 06:49:59
Modify Date: 2024-01-04 20:09:50
PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability[1].

Name	PD-1/PD-L1-IN-32

Description	PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
Target	IC50: 2.4 nM (PD-1/PD-L1)[1]
References	[1]. Zhang H, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66(15):10579-10603.

Molecular Formula	C₂₉H₂₅ClFN₃O₃
Molecular Weight	517.98