2308548-54-9

2308548-54-9 structure

Name: MeOIstPyrd
Chemical Name: MeOIstPyrd
CAS Number: 2308548-54-9
Molecular Formula: C₁₄H₁₆N₄O₂S
Molecular Weight: 304.37
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2023-11-01 09:22:36
Modify Date: 2024-01-04 15:35:17
MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction[1].

Name	MeOIstPyrd

Description	MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
References	[1]. Nerina Shahi, et al. 5-Methoxyisatin N(4)-Pyrrolidinyl Thiosemicarbazone (MeOIstPyrd) Restores Mutant p53 and Inhibits the Growth of Skin Cancer Cells, In Vitro. https://pubs.acs.org/doi/10.1021/acsomega.3c03824. ACS Omega 2023, 8, 35, 31998鈥?2016.

Molecular Formula	C₁₄H₁₆N₄O₂S
Molecular Weight	304.37