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2676177-63-0

2676177-63-0 structure

2676177-63-0 structure

Name: LUNA18
Chemical Name: LUNA18
CAS Number: 2676177-63-0
Molecular Formula: C₇₃H₁₀₅F₅N₁₂O₁₂
Molecular Weight: 1437.68
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2024-04-07 16:21:57
Modify Date: 2025-08-24 16:58:54
LUNA18 is an orally active KRAS inhibitor with an IC50 of ＜2 nM against KRASG12D-SOS. LUNA18 can be used for the research of cancer[1].

Name	LUNA18

Description	LUNA18 is an orally active KRAS inhibitor with an IC50 of ＜2 nM against KRASG12D-SOS. LUNA18 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	IC50: ＜2 nM (KRASG12D-SOS)[1] 0.043 nM (KRASG12D)[1]
References	[1]. Tanada M, et al. Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor. J Am Chem Soc. 2023 Aug 2;145(30):16610-16620.

Molecular Formula	C₇₃H₁₀₅F₅N₁₂O₁₂
Molecular Weight	1437.68

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