2857868-82-5

2857868-82-5 structure

Name: CD38 inhibitor 3
Chemical Name: CD38 inhibitor 3
CAS Number: 2857868-82-5
Molecular Formula: C₁₆H₁₄F₃N₇O₃
Molecular Weight: 409.32
Catalog: Research Areas Metabolic Disease
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CD38 inhibitor 3 (compound 1) is a potent CD38 inhibitor (IC50=11 nM). CD38 inhibitor 3 can promote mitochondrial biogenesis, reduce lactate levels, and increase NAD+ content and Nrf2 expression. In a model of mitochondrial myopathy, CD38 inhibitor 3 increases muscle contraction/development and improves exercise tolerance in Pus1-/- mice[1].

Name	CD38 inhibitor 3

Description	CD38 inhibitor 3 (compound 1) is a potent CD38 inhibitor (IC50=11 nM). CD38 inhibitor 3 can promote mitochondrial biogenesis, reduce lactate levels, and increase NAD+ content and Nrf2 expression. In a model of mitochondrial myopathy, CD38 inhibitor 3 increases muscle contraction/development and improves exercise tolerance in Pus1-/- mice[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	IC50: 11 nM (CD38)[1]
References	[1]. Li Y, et al. Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy. J Med Chem. 2023 Sep 11.. .

Molecular Formula	C₁₆H₁₄F₃N₇O₃
Molecular Weight	409.32