504428-17-5

504428-17-5 structure

Name: (1R,3S)-Compound E
Chemical Name: (1R,3S)-Compound E
CAS Number: 504428-17-5
Molecular Formula: C₂₇H₂₄F₂N₄O₃
Molecular Weight: 490.50
Catalog: Research Areas Cancer
Create Date:
Modify Date:
(1R,3S)-Compound E is the inactive isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

Name	(1R,3S)-Compound E

Description	(1R,3S)-Compound E is the inactive isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402. [2]. Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88.

Molecular Formula	C₂₇H₂₄F₂N₄O₃
Molecular Weight	490.50