327077-97-4
327077-97-4 structure
- Name: 41F5
- Chemical Name: 41F5
- CAS Number: 327077-97-4
- Molecular Formula: C21H22N2OS
- Molecular Weight: 350.48
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2024-09-15 18:14:47
- Modify Date: 2024-09-15 18:14:47
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41F5 is anti-fugal agent. 41F5 is highly active against Histoplasma yeast (MIC50 0.4-0.8 μM). 41F5 has fungistatic activity against Histoplasma yeast with a 50% inhibitory concentration (IC50) of 0.87 μM, and has the greatest selectivity for yeast (at least 62-fold) relative to host cells.
| Name | 41F5 |
|---|
| Description | 41F5 is anti-fugal agent. 41F5 is highly active against Histoplasma yeast (MIC50 0.4-0.8 μM). 41F5 has fungistatic activity against Histoplasma yeast with a 50% inhibitory concentration (IC50) of 0.87 μM, and has the greatest selectivity for yeast (at least 62-fold) relative to host cells. |
|---|---|
| References | 1. Khalil A, Edwards JA, Rappleye CA, Tjarks W. Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans. Bioorg Med Chem. 2015 Feb 1;23(3):532-47. doi: 10.1016/j.bmc.2014.12.006. Epub 2014 Dec 10. PubMed PMID: 25543205; PubMed Central PMCID: PMC4302056. |
| Molecular Formula | C21H22N2OS |
|---|---|
| Molecular Weight | 350.48 |