2763602-67-9
2763602-67-9 structure
- Name: TGFβRI-IN-3
- Chemical Name: TGFβRI-IN-3
- CAS Number: 2763602-67-9
- Molecular Formula: C28H23N3O2S
- Molecular Weight: 465.57
- Create Date: 2026-07-05 13:35:33
- Modify Date: 2026-07-05 13:35:33
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TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology [1].
| Name | TGFβRI-IN-3 |
|---|
| Description | TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology [1]. |
|---|---|
| In Vitro | TGFβRI-IN-3 inhibits TGFβR1 at an IC 50 of 0.79 nM, 2000-fold selectivity for MAP4K4 [1]. |
| References | 1. Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763. |
| Molecular Formula | C28H23N3O2S |
|---|---|
| Molecular Weight | 465.57 |