2448341-58-8
2448341-58-8 structure
- Name: NV03
- Chemical Name: NV03
- CAS Number: 2448341-58-8
- Molecular Formula: C19H27N5O2S
- Molecular Weight: 389.51
- Create Date: 2024-03-04 18:32:45
- Modify Date: 2024-03-04 18:32:45
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NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a K d of 2.4 μM. NV03 is a possible application as anticancer therapeutics [1].
| Name | NV03 |
|---|
| Description | NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a K d of 2.4 μM. NV03 is a possible application as anticancer therapeutics [1]. |
|---|---|
| References | 1. Senisterra G, et al. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. SLAS Discov. 2018 Oct;23(9):930-940. |
| Molecular Formula | C19H27N5O2S |
|---|---|
| Molecular Weight | 389.51 |