1254979-66-2
1254979-66-2 structure
- Name: JNJ-46356479
- Chemical Name: JNJ-46356479
- CAS Number: 1254979-66-2
- Molecular Formula: C22H22F5N5
- Molecular Weight: 451.44
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2024-10-06 18:32:33
- Modify Date: 2024-10-06 18:32:33
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JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256.
| Name | JNJ-46356479 |
|---|
| Description | JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256. |
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| References | 1. Cid JM, Tresadern G, Vega JA, de Lucas AI, Del Cerro A, Matesanz E, Linares ML, García A, Iturrino L, Pérez-Benito L, Macdonald GJ, Oehlrich D, Lavreysen H, Peeters L, Ceusters M, Ahnaou A, Drinkenburg W, Mackie C, Somers M, Trabanco AA. Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). J Med Chem. 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27579727. |
| Molecular Formula | C22H22F5N5 |
|---|---|
| Molecular Weight | 451.44 |