1420290-88-5

1420290-88-5 structure

Name: HJC0152 free base
Chemical Name: HJC0152
CAS Number: 1420290-88-5
Molecular Formula: C₁₅H₁₃Cl₂N₃O₄
Molecular Weight: 370.19
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-11-27 15:57:14
Modify Date: 2025-08-24 19:26:24
HJC0152 (free base) is an orally active and potent inhibitor of STAT3. HJC0152 (free base) inhibits cell cycle progression and induces apoptosis. HJC0152 (free base) significantly suppresses MDA-MB-231 xenograft tumor growth in mice[1].

Name	HJC0152
Synonyms	compound 11 compound 11 [WO2014113467A1] HJC-0152 HJC-1-52

Description	HJC0152 (free base) is an orally active and potent inhibitor of STAT3. HJC0152 (free base) inhibits cell cycle progression and induces apoptosis. HJC0152 (free base) significantly suppresses MDA-MB-231 xenograft tumor growth in mice[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
References	[1]. Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185.