1900754-56-4

1900754-56-4 structure

Name: Zamaporvint
Chemical Name: Zamaporvint
CAS Number: 1900754-56-4
Molecular Formula: C₂₁H₁₆F₃N₇O
Molecular Weight: 439.39
Catalog: Signaling Pathways Stem Cell/Wnt Porcupine
Create Date: 2023-10-17 22:41:43
Modify Date: 2024-04-03 12:19:41
Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. Zamaporvint targete membrane-bound o-acyltransferase Porcupine and inhibited Wnt ligand palmitoylation, secretion, and pathway activation. Zamaporvint displays a favorable pharmacokinetic profile and shows potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines. Zamaporvint possesses multiple antitumor mechanisms and can be used in cancer research[1].

Name	Zamaporvint

Description	Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. Zamaporvint targete membrane-bound o-acyltransferase Porcupine and inhibited Wnt ligand palmitoylation, secretion, and pathway activation. Zamaporvint displays a favorable pharmacokinetic profile and shows potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines. Zamaporvint possesses multiple antitumor mechanisms and can be used in cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Signaling Pathways >> Stem Cell/Wnt >> Porcupine
References	[1]. Phillips C, The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand-dependent Cancer Models. Cancer Res Commun. 2022 Sep 2;2(9):914-928.

Molecular Formula	C₂₁H₁₆F₃N₇O
Molecular Weight	439.39