2938220-60-9

2938220-60-9 structure

Name: HP661
Chemical Name: HP661
CAS Number: 2938220-60-9
Molecular Formula: C₃₁H₂₉F₆N₇O₃
Molecular Weight: 661.60
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-10-18 17:24:41
Modify Date: 2024-01-14 16:56:33
HP661 is an orally available oxidative phosphorylation (OXPHOS) inhibitor that effectively blocks the activity of mitochondrial complex I and reduces the production of the reactive oxygen species. HP661 can abrogate the growth of high OXPHOS-dependent tumors, conquer high OXPHOS-mediated drug resistance, and can induce cell apoptosis. And HP661 can be used for anti-tumor research[1].

Name	HP661

Description	HP661 is an orally available oxidative phosphorylation (OXPHOS) inhibitor that effectively blocks the activity of mitochondrial complex I and reduces the production of the reactive oxygen species. HP661 can abrogate the growth of high OXPHOS-dependent tumors, conquer high OXPHOS-mediated drug resistance, and can induce cell apoptosis. And HP661 can be used for anti-tumor research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. He P, et.al. Discovery of a Potent and Oral Available Complex I OXPHOS Inhibitor That Abrogates Tumor Growth and Circumvents MEKi Resistance. J Med Chem. 2023 May 11;66(9):6047-6069.

Molecular Formula	C₃₁H₂₉F₆N₇O₃
Molecular Weight	661.60