2378768-36-4

2378768-36-4 structure

Name: DDO-2213
Chemical Name: DDO-2213
CAS Number: 2378768-36-4
Molecular Formula: C₂₄H₂₇ClFN₇O
Molecular Weight: 483.97
Catalog: Research Areas Cancer
Create Date: 2023-09-26 05:29:21
Modify Date: 2024-04-13 08:32:35
DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research[1].

Name	DDO-2213

Description	DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Chen W, et al. Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5-Mixed Lineage Leukemia 1 Protein-Protein Interaction for the Treatment of MLL Fusion Leukemia. J Med Chem. 2021 Jun 24;64(12):8221-8245.

Molecular Formula	C₂₄H₂₇ClFN₇O
Molecular Weight	483.97