2923365-71-1

2923365-71-1 structure

Name: CH7233163
Chemical Name: CH7233163
CAS Number: 2923365-71-1
Molecular Formula: C₃₁H₃₄F₃N₉O₃S
Molecular Weight: 669.72
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-11-14 14:46:49
Modify Date: 2025-08-20 21:35:05
CH7233163 is a noncovalent ATP-competitive inhibitor for EGFR-Del19/T790M/C797S. CH7233163 can overcome Osimertinib (HY-15772)-Resistant EGFR-Del19/T790M/C797S mutation. CH7233163 blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 has antitumor activities[1].

Name	CH7233163

Description	CH7233163 is a noncovalent ATP-competitive inhibitor for EGFR-Del19/T790M/C797S. CH7233163 can overcome Osimertinib (HY-15772)-Resistant EGFR-Del19/T790M/C797S mutation. CH7233163 blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 has antitumor activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Kashima K, et al. CH7233163 Overcomes Osimertinib-Resistant EGFR-Del19/T790M/C797S Mutation. Mol Cancer Ther. 2020 Nov;19(11):2288-2297.

Molecular Formula	C₃₁H₃₄F₃N₉O₃S
Molecular Weight	669.72