76735-57-4

76735-57-4 structure

Name: Cannflavin A
Chemical Name: Cannflavin A
CAS Number: 76735-57-4
Molecular Formula: C₂₆H₂₈O₆
Molecular Weight: 436.50
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-11-03 13:15:10
Modify Date: 2025-08-25 16:29:02
Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage[1][2][3][4].

Name	Cannflavin A

Description	Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Rea KA, et al. Biosynthesis of cannflavins A and B from Cannabis sativa L. Phytochemistry. 2019 Aug;164:162-171. [2]. Eggers C, et al. Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: Comparison with geranylated flavonoids, mimulone and diplacone. Biochem Pharmacol. 2019 Nov;169:113609. [3]. Puopolo T, et al. Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase. Biology (Basel). 2022 Sep 28;11(10):1416. [4]. Tomko AM, et al. Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer. J Cannabis Res. 2022 Jul 22;4(1):41.

Molecular Formula	C₂₆H₂₈O₆
Molecular Weight	436.50