2760536-88-5
2760536-88-5 structure
- Name: Bcl-2-IN-11
- Chemical Name: Bcl-2-IN-11
- CAS Number: 2760536-88-5
- Molecular Formula: C45H49ClFN7O8S
- Molecular Weight: 902.43
- Catalog: Signaling Pathways Apoptosis Bcl-2 Family
- Create Date: 2023-10-18 15:45:18
- Modify Date: 2024-01-29 19:35:05
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Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1].
| Name | Bcl-2-IN-11 |
|---|
| Description | Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1]. |
|---|---|
| Related Catalog | |
| Target |
Bcl-2:0.9 nM (IC50) Bcl-xL:>1000 nM (IC50) |
| References |
[1]. Kong Xianglong, et al. Heterocyclic compound as bcl-2 inhibitor. WO2022028353A1. |
| Molecular Formula | C45H49ClFN7O8S |
|---|---|
| Molecular Weight | 902.43 |