2172852-12-7

2172852-12-7 structure

Name: Vupanorsen sodium
Chemical Name: Vupanorsen sodium
CAS Number: 2172852-12-7
Molecular Formula: C₂₉₆H₄₁₄N₈₆Na₂₀O₁₅P₂₀S₁₃
Molecular Weight: 9105.04
Catalog: Research Areas Metabolic Disease
Create Date: 2023-07-25 09:30:16
Modify Date: 2025-09-18 15:18:23
Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins.

Name	Vupanorsen sodium

Description	Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Bergmark BA, Marston NA, Bramson CR, et al. Effect of Vupanorsen on Non-High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70. Circulation. 2022;145(18):1377-1386. [2]. Gaudet D, Karwatowska-Prokopczuk E, Baum SJ, et al. Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia. Eur Heart J. 2020;41(40):3936-3945.

Molecular Formula	C₂₉₆H₄₁₄N₈₆Na₂₀O₁₅P₂₀S₁₃
Molecular Weight	9105.04