2408723-12-4
2408723-12-4 structure
- Name: STING agonist-22
- Chemical Name: STING agonist-22
- CAS Number: 2408723-12-4
- Molecular Formula: C40H48N14O6
- Molecular Weight: 820.90
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2023-06-18 16:26:33
- Modify Date: 2024-01-11 14:57:58
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STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research[1].
| Name | STING agonist-22 |
|---|
| Description | STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research[1]. |
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| Related Catalog | |
| In Vitro | STING agonist-22 (CF501) 导致 THP-1 细胞中先天免疫反应的快速和强烈激活[1]。 |
| In Vivo | STING agonist-22 (CF501) 以可接受的安全性在小鼠中稳健但短暂地激活先天免疫[1]。 Animal Model: Balb/c mice (female, six weeks old)[1] Dosage: 20, 75 μg Administration: Intramuscular injection Result: Although innate immunity was activated only transiently by CF501, it should be sufficient to stimulate the required humoral and cellular immune responses. The half-life of CF501 was 0.5 h and there was no detectable CF501 in the plasma after 2 h of the injection. |
| References |
| Molecular Formula | C40H48N14O6 |
|---|---|
| Molecular Weight | 820.90 |