2097587-83-0

2097587-83-0 structure

Name: Olezarsen
Chemical Name: Olezarsen
CAS Number: 2097587-83-0
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Cardiovascular Disease
Create Date: 2023-07-06 22:08:56
Modify Date: 2025-08-25 01:37:42
Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.

Name	Olezarsen

Description	Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J. 2022;43(14):1401-1412. [2]. Karwatowska-Prokopczuk E, Tardif JC, Gaudet D, et al. Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia. J Clin Lipidol. 2022;16(5):617-625.

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