2639608-44-7
2639608-44-7 structure
- Name: MRTX-1257-d6
- Chemical Name: MRTX-1257-d6
- CAS Number: 2639608-44-7
- Molecular Formula: C33H33D6N7O2
- Molecular Weight: 571.75
- Catalog: Research Areas Cancer
- Create Date: 2023-06-20 10:26:09
- Modify Date: 2024-04-09 23:53:10
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MRTX-1257-d6 is the deuterium labeled MRTX-1257 (HY-114436). MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells[1][2].
| Name | MRTX-1257-d6 |
|---|
| Description | MRTX-1257-d6 is the deuterium labeled MRTX-1257 (HY-114436). MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells[1][2]. |
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| Related Catalog | |
| In Vitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 |
| References |
| Molecular Formula | C33H33D6N7O2 |
|---|---|
| Molecular Weight | 571.75 |