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2765539-59-9

2765539-59-9 structure

2765539-59-9 structure

Name: LSN3160440
Chemical Name: LSN3160440
CAS Number: 2765539-59-9
Molecular Formula: C₂₇H₂₇Cl₂N₃O
Molecular Weight: 480.43
Catalog: Research Areas Metabolic Disease
Create Date: 2023-07-08 10:56:43
Modify Date: 2025-08-25 18:58:05
LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein–protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R[1][2].

Name	LSN3160440

Description	LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein–protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R[1][2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	LSN3160440 binds between the TM1 and TM2 interfaces of GLP-1R, and the benzimidazole group of LSN3160440 interacts with GLP-1R in a variety of ways, such as van der Waals contacts with Leu142, π‒π stacking with Tyr145, and frequent water bridging with Lys202[1].
References	[1]. Hui-Jun Liao, et al. Investigating Potential GLP-1 Receptor Agonists in Cyclopeptides from Pseudostellaria heterophylla, Linum usitatissimum, and Drymaria diandra, and Peptides Derived from Heterophyllin B for the Treatment of Type 2 Diabetes: An In Silico Study. Metabolites. 2022 Jun 15;12(6):549. [2]. Hongyu Wu, et al. Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment. Acta Pharm Sin B. 2022 Sep;12(9):3548-3566.

Molecular Formula	C₂₇H₂₇Cl₂N₃O
Molecular Weight	480.43

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