2259641-47-7
2259641-47-7 structure
- Name: Ep300/CREBBP-IN-3
- Chemical Name: Ep300/CREBBP-IN-3
- CAS Number: 2259641-47-7
- Molecular Formula: C26H25F4N5O3
- Molecular Weight: 531.50
- Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
- Create Date: 2023-08-03 10:31:29
- Modify Date: 2024-01-02 19:38:37
-
Ep300/CREBBP-IN-3 (Example 61) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.056 and 0.095 μM, respectively. Ep300/CREBBP-IN-3 can be used for the research of cancer[1].
| Name | Ep300/CREBBP-IN-3 |
|---|
| Description | Ep300/CREBBP-IN-3 (Example 61) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.056 and 0.095 μM, respectively. Ep300/CREBBP-IN-3 can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
EP300:0.056 μM (IC50) CREBBP:0.095 μM (IC50) |
| In Vitro | Ep300/CREBBP-IN-3 (Example 61) 抑制细胞内 H3K27Ac 活性，其 IC50 为 0.021 μM[1]。 Ep300/CREBBP-IN-3 (38 nM-10 mM; 3 days) 抑制 LK2 和 TE-8 细胞生长，GI50 分别为 148.858 μM 和 215.717 μM [1]。 Cell Viability Assay[1] Cell Line: LK2 and TE-8 cells Concentration: 38 nM-10 mM Incubation Time: 3 days Result: Inhibited LK2 and TE-8 cell growth with GI50s of 148.858 and 215.717 μM, respectively. |
| References |
[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1. |
| Molecular Formula | C26H25F4N5O3 |
|---|---|
| Molecular Weight | 531.50 |