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354155-51-4

354155-51-4 structure
354155-51-4 structure
  • Name: Endochin
  • Chemical Name: Endochin
  • CAS Number: 354155-51-4
  • Molecular Formula: C18H25NO2
  • Molecular Weight: 287.40
  • Catalog: Research Areas Infection
  • Create Date: 2023-06-24 20:51:53
  • Modify Date: 2025-08-25 12:12:52
  • Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis[1][2].

Name Endochin
Description Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis[1][2].
Related Catalog
In Vitro Endochin 抑制弓形虫细胞色素 bc1 复合物对细胞色素 c 的还原,IC50 为 8.2 nM[1]。 Endochin 抑制 T. gondii 的 IC50 为 0.003 nM[1]。 Endochin (Compound 1) 抑制 Plasmodium falciparum 分离出的多重耐药 W2 和 TM90-C2B 分离株,IC50 分别为 8.59 和 46.6 nM[2]。
References

[1]. Doggett JS, et al. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41.  

[2]. Cross RM, et al. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct 14;53(19):7076-94.  

Molecular Formula C18H25NO2
Molecular Weight 287.40
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