2408590-36-1
2408590-36-1 structure
- Name: CWI1-2
- Chemical Name: CWI1-2
- CAS Number: 2408590-36-1
- Molecular Formula: C22H17Cl3N6O3
- Molecular Weight: 519.77
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-08-11 14:39:12
- Modify Date: 2024-01-10 15:21:04
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CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1].
| Name | CWI1-2 |
|---|---|
| Synonyms | NND-2341703 |
| Description | CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1]. |
|---|---|
| Related Catalog | |
| In Vitro | CWI1-2 (0-1 μM, 24 h) 具有良好的抗白血病功效[1]。 Apoptosis Analysis[1] Cell Line: MonoMac6, MOLM13 Concentration: 0-1 μM Incubation Time: 24 h Result: Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells. Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells. Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC. |
| In Vivo | CWI1-2（5 mg/kg，i.v.，每日一次，7-10天）可显着延缓 BMT 受体 B6.SJL（CD45.1）小鼠白血病的发生和存活时间，体重无明显影响 [1]。 |
| References |
| Molecular Formula | C22H17Cl3N6O3 |
|---|---|
| Molecular Weight | 519.77 |