1593741-99-1
1593741-99-1 structure
- Name: Axinelline A
- Chemical Name: Axinelline A
- CAS Number: 1593741-99-1
- Molecular Formula: C12H15NO6
- Molecular Weight: 269.25
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2023-07-18 23:43:42
- Modify Date: 2025-08-21 06:42:16
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Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity[1].
| Name | Axinelline A |
|---|
| Description | Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity[1]. |
|---|---|
| Related Catalog | |
| Target |
COX-2:2.22 μM (IC50) COX-1:8.89 μM (IC50) |
| In Vitro | Axinelline A (2-30 μM; 24 h) 抑制脂多糖 (LPS; HY-D1056) 诱导的 RAW264.7 细胞中促炎因子 (NO、TNF-α、IL-6、IL-1β 和 PGE2) 的表达[1]。 Axinelline A (2-30 μM; 24 h) 抑制 LPS 诱导的 RAW264.7 细胞 NF-κB 信号通路[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 2, 10 and 30 μM Incubation Time: 24 h Result: Diminished LPS-induced expression of nitric oxide synthase (iNOS) and COX-2 protein levels. The phosphorylation level of NF-κB increased after 30 min of LPS treatment, but pretreatment with test compound reduced the level of phosphorylation in a dose-dependent manner. The phosphorylation of IKK and IκBα was inhibited in a dose-dependent manner. |
| References |
| Molecular Formula | C12H15NO6 |
|---|---|
| Molecular Weight | 269.25 |