2901064-07-9
2901064-07-9 structure
- Name: Antifungal agent 84
- Chemical Name: Antifungal agent 84
- CAS Number: 2901064-07-9
- Molecular Formula: C25H19BrClFN6O
- Molecular Weight: 553.81
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2023-06-11 19:52:13
- Modify Date: 2024-01-18 12:53:54
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Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability[1].
| Name | Antifungal agent 84 |
|---|
| Description | Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Antibacterial agent 84 (化合物 6d) (1-16 μg/mL) 抑制人类病原体 C. albicans SC5314 生长[1]. Antibacterial agent 84 (16 μg/mL，18 小时) 以 CNB1 依赖性方式诱导 C. albicans 内源性活性氧 (ROS) 的产生[1]。 Antibacterial agent 84 (16 μg/mL，18 小时) 对 C. albicans 中的溶酶体膜透化作用具有细胞毒性[1]. Antibacterial agent 84 (16 μg/mL，18 小时) 诱导 C. albicans 被巨噬细胞吞噬[1]。 Antibacterial agent 84 (0.06-32 μg/mL) 抑制 C. albicans 和 C. tropicalis 培养物中的麦角固醇合成[1]。 Cell Viability Assay[1] Cell Line: C. albicans (SC5314) Concentration: 1-16 μg/mL Incubation Time: 18 or 48 h Result: Inhibited C. albicans SC5314 growth by nearly 100%. |
| In Vivo | 抗菌剂 84 (16 μg/mL，注入右前腿) 有助于在感染后 1 小时清除被 C. albicans 感染的 G. mellonella 幼虫[1]。 Animal Model: G. mellonella larvae infected by C. albicans[1] Dosage: 16 μg/mL Administration: Injected into the right pro-leg of the last instar larvae. Result: Realized the clearance of fungi 1 h post-infection. |
| References |
| Molecular Formula | C25H19BrClFN6O |
|---|---|
| Molecular Weight | 553.81 |