824960-50-1

824960-50-1 structure

824960-50-1 structure

Name: WDR5-0102
Chemical Name: WDR5-0102
CAS Number: 824960-50-1
Molecular Formula: C₁₈H₁₉ClN₄O₃
Molecular Weight: 374.82
Catalog: Research Areas Cancer
Create Date: 2023-05-31 18:48:04
Modify Date: 2023-05-31 18:48:04
WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5[1][2].

Name	WDR5-0102

Description	WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645. [2]. Chen X, et al. Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective. J Med Chem. 2021 Aug 12;64(15):10537-10556.

Molecular Formula	C₁₈H₁₉ClN₄O₃
Molecular Weight	374.82