2419087-89-9
2419087-89-9 structure
- Name: Mazorelvimab
- Chemical Name: Mazorelvimab
- CAS Number: 2419087-89-9
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Infection
- Create Date: 2023-06-11 15:24:12
- Modify Date: 2024-01-14 10:46:22
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Mazorelvimab (SYN023) is a combination of CTB011 and CTB012 humanized monoclonal antibodies cocktail against rabies virus (RABV). Mezagitamab binds to non-overlapping epitopes on RABV glycoprotein (G). Mezagitamab has potential application in the prevention of rabies[1][2].
| Name | Mazorelvimab |
|---|
| Description | Mazorelvimab (SYN023) is a combination of CTB011 and CTB012 humanized monoclonal antibodies cocktail against rabies virus (RABV). Mezagitamab binds to non-overlapping epitopes on RABV glycoprotein (G). Mezagitamab has potential application in the prevention of rabies[1][2]. |
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| Related Catalog | |
| In Vitro | Mazorelvimab (0.01-100 µg/mL) 以剂量依赖性方式对 CVS-11 感染的 BSR 细胞显示出细胞毒性，但对未感染的 BSR 细胞无影响[1]。 |
| In Vivo | Mazorelvimab (0.03-1.0 mg/kg；肌肉注射；单剂量) 以剂量依赖性方式提高了被狂犬病毒 (RABV) 感染的仓鼠的存活率[1]。 Mazorelvimab (0.003-1mg/kg；肌肉注射；单剂量) 以剂量依赖性方式提高 RABV 感染的仓鼠的存活率。Mazorelvimab (0.003-0.03 mg/kg) 对未感染病毒的叙利亚仓鼠血清 RVNA 水平无显著干扰[2]。 Mazorelvimab (0.03-1 mg/kg；肌肉注射；单剂量) 对感染 RABV (BD06) 的比格犬具有保护作用[2]。 Animal Model: RABV infected Syrian hamster[1]. Dosage: 0.03, 0.1, 0.3 and 1.0 mg/kg. Administration: Right gastrocnemius muscle injection; single dose. Result: Improved the survival rate. Animal Model: 10 two-month-old female Syrian hamsters/six-month-old beagles infected with RABV (BD06)[2]. Dosage: 0.003, 0.01, 0.03, 0.1, 0.3 and 1 mg/kg. Administration: Right gastrocnemius muscle or masseter muscle injection; single dose. Result: Improved survival rate and had protective effect. |
| References |
| No Any Chemical & Physical Properties |