1030936-22-1

1030936-22-1 structure

1030936-22-1 structure

Name: Losartan-d2
Chemical Name: Losartan-d2
CAS Number: 1030936-22-1
Molecular Formula: C₂₂H₂₁D₂ClN₆O
Molecular Weight: 424.92
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2023-05-28 13:12:29
Modify Date: 2023-05-28 13:12:29
Losartan-d2 is the deuterium labeled Losartan[1]. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM[2].

Name	Losartan-d2

Description	Losartan-d2 is the deuterium labeled Losartan[1]. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12.;Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.

Molecular Formula	C₂₂H₂₁D₂ClN₆O
Molecular Weight	424.92