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37648-76-3

37648-76-3 structure
37648-76-3 structure
  • Name: VU661
  • Chemical Name: VU661
  • CAS Number: 37648-76-3
  • Molecular Formula: C19H13N3O
  • Molecular Weight: 299.33
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2023-06-06 00:23:21
  • Modify Date: 2025-08-27 11:20:18
  • VU661, a phenazine carboxamide, is a modulator of circadian rhythms to produce a period lengthening of the circadian rhythm. VU661 is a redox-active small molecule [1].

Name VU661
Description VU661, a phenazine carboxamide, is a modulator of circadian rhythms to produce a period lengthening of the circadian rhythm. VU661 is a redox-active small molecule [1].
Related Catalog
In Vitro VU661 (1, 3, 10 μM; 0-144 小时) 以剂量依赖的方式产生周期延长效应 (10 μM 时为 7.2 小时),并且对 Bmal1-dLuc U2OS 细胞系的振幅影响最小[1]。 VU661 (1, 10 μM; 24小时) 在细胞中以剂量依赖性方式增加光学氧化还原比[1]。 VU661 对细胞 ROS 或过氧化氢水平几乎没有影响[1]。
References

[1]. Kevin P Kelly, et al. Screen for Small-Molecule Modulators of Circadian Rhythms Reveals Phenazine as a Redox-State Modifying Clockwork Tuner. ACS Chem Biol. 2022 Jul 15;17(7):1658-1664.  

Molecular Formula C19H13N3O
Molecular Weight 299.33
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