2429877-78-9

2429877-78-9 structure

Name: PROTAC STAT3 degrader-2
Chemical Name: PROTAC STAT3 degrader-2
CAS Number: 2429877-78-9
Molecular Formula: C₅₉H₆₀F₂N₉O₁₃P
Molecular Weight: 1172.13
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2023-04-15 16:03:22
Modify Date: 2024-04-05 14:06:31
PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research[1].

Name	PROTAC STAT3 degrader-2

Description	PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> PROTAC >> PROTAC
Target	STAT3:3.54 μM (ID50)
In Vitro	PROTAC STAT3 degrader-2 (compound 27; 4 天) 在 Molm-16 具有细胞生长抑制活性，IC50 为 0.582 μM，对 SU-DHL-1 细胞作用低，IC50>10 μM[1]。 PROTAC STAT3 degrader-2 在高达 5 μM 无法降低 SU-DHL-1 细胞中的 STAT3 和 pSTATSY705 蛋白水平[1]。
References	[1]. Haibin Zhou, et al. Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. J Med Chem. 2019 Dec 26;62(24):11280-11300.

Molecular Formula	C₅₉H₆₀F₂N₉O₁₃P
Molecular Weight	1172.13