2832887-40-6
2832887-40-6 structure
- Name: M5N36
- Chemical Name: M5N36
- CAS Number: 2832887-40-6
- Molecular Formula: C20H16ClN5O3
- Molecular Weight: 409.83
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2023-04-21 10:29:02
- Modify Date: 2024-04-06 09:39:18
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M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2[1].
| Name | M5N36 |
|---|
| Description | M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2[1]. |
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| Related Catalog | |
| Target |
IC50: 0.15 µM (Cdc25A); 0.19 µM (Cdc25B); 0.06 µM (Cdc25C)[1] |
| In Vitro | M5N36 (5, 10 µM; 24 h) 增加 MDA-MB-231 细胞中 p-CDK1 和 p-CDK2 的表达[1]。 Cell Proliferation Assay[1] Cell Line: Eca-109, HepG2, MCF-TAM, MDA-MB-231, Raji, SGC-7901, SW-620, HUVEC cells Concentration: Incubation Time: Result: Showed anti-proliferative activity with IC50s of 2.88, 3.57, 10.00, 2.00, 1.20, 6.03, 3.39, 2.40 µM for Eca-109, HepG2, MCF-TAM, MDA-MB-231, Raji, SGC-7901, SW-620, HUVEC cells, respectively. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 5, 10 µM Incubation Time: 24 h Result: Increased the expression of Cdc25A, Cdc25B, increased the expression of p-CDK1 and p-CDK2. |
| References |
| Molecular Formula | C20H16ClN5O3 |
|---|---|
| Molecular Weight | 409.83 |