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2042629-43-4

2042629-43-4 structure

2042629-43-4 structure

Name: JAK-IN-24
Chemical Name: JAK-IN-24
CAS Number: 2042629-43-4
Molecular Formula: C₂₀H₂₅N₅O₂
Molecular Weight: 367.44
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2023-04-10 18:27:11
Modify Date: 2025-08-26 14:15:19
JAK-IN-24 is a JAK inhibitor, with IC50s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM[1].

Name	JAK-IN-24

Description	JAK-IN-24 is a JAK inhibitor, with IC50s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
In Vitro	JAK-IN-24 (Example 129) 在 4 μM 或 1mM ATP 存在时抑制 JAK 的 IC50 值分别为 0.534 和 24 nM[1]。 JAK-IN-24 在人全血中表现出稳定性，t1/2 为 267.223 分钟[1]。 JAK-IN-24 抑制 PBMC IL-15 诱导的 STAT5 磷酸化，IC50 为 86.171 nM[1]。
References	[1]. Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof. Patent. WO2016178110.

Molecular Formula	C₂₀H₂₅N₅O₂
Molecular Weight	367.44

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