2485020-60-6
2485020-60-6 structure
- Name: Elarekibep
- Chemical Name: Elarekibep
- CAS Number: 2485020-60-6
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2023-04-18 16:50:07
- Modify Date: 2025-08-26 17:31:59
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Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma[1].
| Name | Elarekibep |
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| Description | Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma[1]. |
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| Related Catalog | |
| In Vitro | Elarekibep (PRS-060) (0-10 µM) 抑制 IL-4 或 IL-13 诱导的 STAT-6 磷酸化，IC50 值分别为 0.12 nM 和 0.10 nM[ 1]. PRS-060 (0-10 µM) 抑制 hIL-4 或 hIL-13 诱导的 TF-1 细胞增殖，IC50 值分别为 0.87 nM 和 0.92 nM[1]< /sup>. PRS-060 (0-10 µM) 抑制 hIL-13 诱导的人上皮细胞粘液转分化，IC50 值为 0.3 nM[1]。 |
| In Vivo | PRS-060（气管内滴注；2、10、50 µg）抑制人源化小鼠肺中 IL-13 诱导的 eotaxin-1 表达和卵清蛋白诱导的急性过敏性炎症[1]。 Animal Model: Triple-humanized mouse model[1] Dosage: 2, 10, 50 µg/mouse Administration: Intratracheal instillation (i.t) Result: Strongly suppressed acute allergic inflammation indices in triple humanized mice. |
| References |
| No Any Chemical & Physical Properties |