2553413-86-6
2553413-86-6 structure
- Name: Dazostinag
- Chemical Name: Dazostinag
- CAS Number: 2553413-86-6
- Molecular Formula: C21H22F2N8O10P2S2
- Molecular Weight: 710.52
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2023-04-25 08:17:19
- Modify Date: 2024-04-07 10:12:40
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Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis Antibody-Drug Conjugates (ADCs)[1][2].
| Name | Dazostinag |
|---|
| Description | Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis Antibody-Drug Conjugates (ADCs)[1][2]. |
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| Related Catalog | |
| In Vitro | Dazostinag (ADC-1，连接子-有效载荷) (121 μM；10 min-24 hr) 在大鼠肝脏三倍体中的半衰期 (t1/2) 为 2.4 小时[1]。 Dazostinag (ADC-1，连接子-有效载荷) 在具有人 STING 的 R232 变体的 THP1 细胞中激活人鸟苷酸环化酶 C (GCC)，EC50 为 0.068 nM[1]。 Dazostinag (ADC-1) (10 μg/mL；0-96 小时) 在人、灵长类动物和小鼠血浆中表现出血浆稳定性[1]。 |
| In Vivo | Dazostinag (ADC-1) (0.1 mg/kg；单剂量) 在携带 CT26-GCC 肿瘤的 Balb/C 小鼠中，半衰期为 33 小时，AUC (last) 值为 51432 h·nM[1]。 Dazostinag (ADC-1) (50 μg/kg，100 μg/kg；静脉注射；单剂量，监测 2 周) 显著抑制 Balb/C 小鼠中、表达 GCC 的 CT26 结肠癌小鼠肿瘤的生长[1]。 Animal Model: CT26 colon carcinoma model in female Balb/C mice (6-8 weeks old)[1] Dosage: 50 μg/kg, 100 μg/kg Administration: IP; single dose, monitored for 15 days, measured two times per week Result: Significantly suppressed the volume of tumor in mice. |
| References |
| Molecular Formula | C21H22F2N8O10P2S2 |
|---|---|
| Molecular Weight | 710.52 |