2642078-60-0
2642078-60-0 structure
- Name: Izeltabart
- Chemical Name: Izeltabart
- CAS Number: 2642078-60-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-03-10 06:25:16
- Modify Date: 2025-08-25 11:39:49
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Izeltabart (IMGC-936) is a Maytansinoid-based ADC targeting ADAM9. Izeltabart is comprised of a high-affinity humanized antibody site-specifically conjugated to DM21-C, a linker-payload that combines a Maytansinoid microtubule-disrupting payload with a stable tripeptide linker, at a drug antibody ratio of approximately 2.0. Izeltabart exhibits cytotoxicity toward ADAM9-positive human tumor cell lines and has potent antitumor activity in xenograft tumor models[1].
| Name | Izeltabart |
|---|
| Description | Izeltabart (IMGC-936) is a Maytansinoid-based ADC targeting ADAM9. Izeltabart is comprised of a high-affinity humanized antibody site-specifically conjugated to DM21-C, a linker-payload that combines a Maytansinoid microtubule-disrupting payload with a stable tripeptide linker, at a drug antibody ratio of approximately 2.0. Izeltabart exhibits cytotoxicity toward ADAM9-positive human tumor cell lines and has potent antitumor activity in xenograft tumor models[1]. |
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| No Any Chemical & Physical Properties |